The study explores the oncogenic functions of the m6A demethylase FTO in breast cancer cells, focusing on its impact on cell proliferation, colony formation, and metastasis. While FTO is known to promote these processes in triple-negative breast cancer (TNBC) models, its specific downstream regulation remains unclear. Transcriptome analysis following FTO knockdown revealed changes related to extracellular matrix (ECM) and epithelial-mesenchymal transition (EMT) genes. The study highlights the importance of FTO for efficient C/EBPβ-LIP expression, suggesting its oncogenic functions through this regulatory mechanism. Additionally, data shows that FTO inhibition leads to reduced cell proliferation and migration in breast cancer cells. The study also delves into the molecular mechanisms underlying FTO's role in breast cancer growth and migration.
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by Zuid... at www.biorxiv.org 09-23-2023
https://www.biorxiv.org/content/10.1101/2023.09.21.558784v1Deeper Inquiries