The study investigates how cells regulate organelle size using cilia as a model. Zebrafish transparency allows observation of IFT across various cilia types, revealing a positive correlation between IFT speed and cilia length. The study challenges conventional factors influencing IFT speed and proposes a novel mechanism based on the size of IFT particles. By analyzing mutants and morphants, the research highlights the importance of IFT train size in regulating ciliary length.
The content delves into the fundamental question of organelle size regulation through an investigation of ciliary length control mechanisms. The study showcases zebrafish as an ideal model for exploring diverse cell types with varying cilia lengths. By examining IFT dynamics and particle sizes, the research uncovers a unique relationship between cilia length and transport speed, challenging existing paradigms in the field.
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by Sun,Y., Chen... at www.biorxiv.org 01-17-2024
https://www.biorxiv.org/content/10.1101/2024.01.16.575975v1Deeper Inquiries