Core Concepts
Triptorelin induces varied gonadotropin responses in women with different conditions.
Abstract
Abstract and Introduction:
- Limited data on endocrine response to triptorelin in women with PCOS or HA.
- Study 1: Triptorelin increased LH similarly in all women, but FSH response was attenuated in PCOS.
- Study 2: FSH levels reduced in women with polycystic ovaries after triptorelin.
- AMH levels negatively correlated with FSH increase post-triptorelin.
Introduction:
- GnRH modifications led to longer-acting GnRHa for reproductive axis stimulation.
- GnRHa can replace hCG in oocyte maturation triggering, especially in PCOS.
- Importance of FSH activity in oocyte maturation remains uncertain.
Stats
The AUC of change in serum FSH was attenuated in women with PCOS compared with healthy women and women with HA (median AUC of change in serum FSH: PCOS, 127.2; healthy, 253.8; HA, 326.7 IU.h/L; P = 0.0005).
FSH levels 4 hours after triptorelin were reduced in women with at least one polycystic morphology ovary (n = 60) vs normal morphology ovaries (n = 91) (34.0 vs 42.3 IU/L; P = 0.0003).
Quotes
"FSH response to triptorelin was attenuated in women with polycystic ovaries, both with and without ovarian stimulation, and was negatively related to AMH levels."