The content discusses two French studies that explored the link between pesticide exposure and the risk of pancreatic cancer.
The first study, EcoPESTIPAC, was a national ecological regression analysis that divided France into 5,529 spatial units. It found an increased risk of pancreatic cancer associated with the cumulative quantity of pesticides used, as well as three specific substances: sulfur in spray form, mancozeb, and glyphosate. A dose-response relationship was observed, where a 2.5 kg/hectare increase in pesticide use over 11 years was linked to a 0.5% increase in pancreatic cancer risk.
The second study, PESTIPAC, was a case-control study conducted at Reims University Hospital. It found an association between the presence of four banned organochlorine pesticides (4,4-DDE, mirex or perchlordecone, trans-nonachlor, and cis-nonachlor) in adipose tissue and an increased risk of pancreatic cancer. The study also noted widespread contamination of these banned substances in both the cancer patients and the control group.
The content highlights that while the associations between pesticide exposure and pancreatic cancer risk are robust, the underlying mechanisms are still poorly understood. Further large-scale studies are needed to confirm these findings and better evaluate the general population's exposure to both banned and currently used pesticides.
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by Vincent Rich... at www.medscape.com 04-03-2024
https://www.medscape.com/viewarticle/certain-pesticides-linked-risk-pancreatic-cancer-2024a100069fDeeper Inquiries