The content explores the impact of resource competition on gene expression and complex trait variance. While resource competition can affect gene expression, it only explains a small fraction of trans-regulation and trait variance. The model suggests that most traits are not significantly influenced by resource competition.
The study introduces a theoretical model of resource competition for polymerases during transcription. It shows that competition among genes for shared intracellular resources has a negligible effect on gene expression variation unless a large fraction of polymerases is bound to core genes. This implies that resource competition is not a major driver of complex trait heritability.
Furthermore, the analysis indicates that while many genes contribute to trait variance, most of the heritability comes from common variants with small effects spread across the genome. The study highlights the importance of considering both cis- and trans-regulatory effects in understanding complex traits.
Overall, the research suggests that resource competition plays a limited role in explaining complex trait heritability and emphasizes the need to consider other factors contributing to genetic variation.
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biorxiv.org
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by Simons,Y. B.... at www.biorxiv.org 03-28-2022
https://www.biorxiv.org/content/10.1101/2022.03.25.485854v2Deeper Inquiries