Core Concepts
Consuming artificial sweeteners alters duodenal microbiome diversity and composition, impacting inflammatory markers.
Abstract
TOPLINE:
NSS consumption affects stool and duodenal microbial diversity.
Changes in levels of circulating inflammatory markers observed.
METHODOLOGY:
REIMAGINE study analyzed NSS effects on duodenal microbiome.
NANS and ASP consumers compared to controls.
Subset provided stool samples for analysis.
TAKEAWAY:
NANS consumers had lower duodenal alpha diversity.
Escherichia, Klebsiella, and Salmonella RA lower in NANS and ASP.
Stool RA of Proteobacteria increased in NANS and ASP.
NANS impacted polysaccharides biosynthesis, ASP enriched cylindrospermopsin biosynthesis.
IN PRACTICE:
Small intestinal microbes crucial for digestion, immune regulation.
Implications for metabolic and gastrointestinal health in US adults.
SOURCE:
Study by Ava Hosseini, MPH, and colleagues at Cedars-Sinai, Los Angeles.
LIMITATIONS:
Study population not representative of healthy individuals.
Small duodenal sample size for aspartame group.
Single timepoint sample collection limits causal relationship establishment.
DISCLOSURES:
Research supported by various charitable trusts.
Authors declared no conflicts of interest.
Stats
Duodenal alpha diversity was lower in NANS consumers vs controls.
Circulating levels of interleukin (IL)-1b were significantly decreased in NANS vs controls.
IL-6 and IL-10 were decreased in the ASP group vs controls.
Quotes
"Given the crucial role played by small intestinal microbes in digestion, nutrient absorption, immune regulation, and endocrine functions..."