Core Concepts
COPD and PRISm predict frailty progression in older adults.
Abstract
Chronic obstructive pulmonary disease (COPD) and preserved ratio impaired spirometry (PRISm) have been linked to the progression of frailty in older adults. A study conducted on over 5000 individuals revealed that individuals with COPD and PRISm experienced accelerated frailty progression compared to those with normal spirometry. The study highlighted the impact of lung function impairment on frailty and the need for further research to understand the underlying mechanisms.
Key Highlights:
- COPD and PRISm associated with frailty progression in older adults.
- Longitudinal data on COPD and frailty progression are limited.
- PRISm defined as proportional impairments in FEV1 and FVC.
- Individuals with PRISm may transition to normal spirometry or COPD.
- Study reviewed data from 5901 adults aged 50 years and older.
- Frailty progression accelerated in patients with PRISm and COPD.
- Results consistent after controlling for confounders.
- Need for more research to explore causality behind the association.
Stats
Frailty progression based on FI was significantly accelerated in patients with PRISm and COPD compared with individuals with normal spirometry, with additional annual increases of 0.301 and 0.172, respectively (P < .001 for both).
Quotes
"PRISm and COPD had independent pathophysiological mechanisms for frailty."
"Results were consistent after controlling for multiple confounders."