Correlation Between Eye Thickness and Kidney Disease

Core Concepts

Changes in eye tissue thickness can predict kidney function.

Abstract

The research explores the correlation between changes in tissue thickness in the back of the eye and kidney function. Key highlights include: Association between chronic kidney disease (CKD) and retinal/choroidal thickness. Thinner retinas and choroids in patients with kidney disease. OCT metrics showing thinner layers in patients with CKD. Choroidal thinning associated with kidney scarring. Improvement in choroidal thickness post kidney transplant. Decrease in macular volume correlating with kidney function decline. Potential for OCT to monitor CKD and kidney transplant patients conveniently. Reversible changes in choroidal thickness post kidney transplantation. Role of ophthalmologists in managing systemic diseases.

Stats

The retina was 5% thinner in patients with CKD than in healthy controls. Patients with CKD had reduced macular volume: 8.44 ± .44 mm3 vs 8.73 ± .36 mm3 (P < .001). At baseline, CKD and transplant patients had significantly lower estimated glomerular filtration rate (eGFR) at 55 ± 27 and 55 ± 24 mL/min/1.73 m2 compared with control volunteers at 97 ± 14 mL/min/1.73 m2. Choroidal thinning at all three macular locations was independently associated with more extensive kidney scarring. For patients with stable CKD, every 1 mm3 decrease in macular volume correlated to an increased odds of a decline in eGFR by more than 10% at 1 year (2.48; 95% CI, 1.26-5.08; P = .01) and by more than 20% at 2 years (3.75; 95% CI, 1.26-5.08; P = .004).

Quotes

"We don't know the exact mechanisms, and these are difficult to define from studies in patients, which is why we are doing more work in animal models of kidney disease to see if we can establish the pathways that lead to the changes in the eye." "It is striking that their findings demonstrate some potential of reversible changes in choroidal perfusion after kidney transplantation." "There are many systemic diseases that can impact the eye and ophthalmologists are uniquely positioned to help interpret those findings."

Key Insights Distilled From

Report: Kidney Disease Evident in These Eye Issues

by Richard Kirk... at www.medscape.com 12-11-2023

https://www.medscape.com/viewarticle/ckd-severity-linked-thinning-retina-choroid-layers-2023a1000v19

Deeper Inquiries

How can the findings of this study impact the early detection and management of kidney disease?

The findings of this study suggest that changes in tissue thickness in the back of the eye, as measured by optical coherence tomography (OCT), can correlate with worsening or improvement of renal problems. This correlation can potentially help in the early detection of kidney disease by monitoring the thickness of the retinal and choroidal layers in patients. By utilizing OCT scans, healthcare providers can track changes in these layers, which may serve as early indicators of kidney function decline. This early detection can prompt timely interventions and management strategies to slow down the progression of kidney disease, ultimately improving patient outcomes.

What are the implications of reversible changes in choroidal thickness post kidney transplantation?

The study's revelation that choroidal thickness changes in chronic kidney disease (CKD) are at least partly reversible with kidney transplantation has significant implications. This finding suggests that kidney transplantation not only improves kidney function but also has a positive impact on ocular health. The reversibility of choroidal thickness post-transplantation indicates a potential link between kidney function and eye health. Understanding and monitoring these changes post-transplantation can provide valuable insights into the overall health status of patients with CKD. It also opens up avenues for further research into the mechanisms underlying these reversible changes and their implications for long-term patient care.

How can collaborations between ophthalmologists and other medical professionals enhance patient care beyond eye-related conditions?

Collaborations between ophthalmologists and other medical professionals can greatly enhance patient care by facilitating a holistic approach to healthcare. Ophthalmologists, with their expertise in eye health and imaging technologies like OCT, can contribute valuable insights into systemic diseases such as chronic kidney disease (CKD). By working closely with nephrologists and other specialists, ophthalmologists can help monitor and manage systemic conditions more effectively. This multidisciplinary approach allows for a comprehensive assessment of patients' health, leading to early detection, timely interventions, and personalized treatment plans. Furthermore, ophthalmologists can play a crucial role in interpreting ocular findings related to systemic diseases, providing valuable information to the broader healthcare team for improved patient care outcomes.