Core Concepts
Heartland virus (HRTV) disease is expanding in the United States, with a fatal case reported in Maryland and Virginia.
Abstract
Abstract:
Heartland virus (HRTV) disease is emerging in the midwestern and southern United States.
A fatal case of HRTV infection was reported in Maryland and Virginia.
Introduction:
HRTV is a tickborne illness spread by Amblyomma americanum ticks.
Cases of HRTV infection are severe, especially in men over 50 with underlying conditions.
Symptoms of HRTV infection include febrile illness, malaise, myalgias, and gastrointestinal distress.
Deaths from HRTV infection have been associated with secondary hemophagocytic lymphohistiocytosis (HLH).
HRTV cases have been reported in multiple states in the US.
The distribution of A. americanum ticks is expanding, possibly due to climate change.
Vertebrate animals with HRTV-neutralizing antibodies have been found in states without confirmed human cases.
A fatal human case of HRTV infection with secondary HLH occurred in Maryland or Virginia.
Stats
Most reported hospitalized patients recover from HRTV infection.
Deaths from HRTV infection have been associated with secondary HLH.
HRTV cases have been reported in multiple states in the US.
Vertebrate animals with HRTV-neutralizing antibodies have been found in states without confirmed human cases.
Quotes
"Many cases of HRTV infection have been characterized by severe illness or death, mostly among men >50 years of age with multiple underlying conditions."
"The range of HRTV could be expanding in the United States."