Hair-Straightening Products Linked to Acute Kidney Failure Risk

Core Concepts

Hair-straightening products containing glyoxylic acid pose a risk of acute kidney failure due to calcium oxalate crystal accumulation.

Abstract

The use of hair-straightening products with glyoxylic acid can lead to acute kidney failure due to calcium oxalate crystal buildup. French researchers observed severe kidney failure in mice within 24 hours of applying the product. The presence of calcium oxalate crystals in renal tubules was confirmed. The researchers recommend avoiding products with glyoxylic acid and withdrawing them from the market. Renal complications may be underdiagnosed, with signs like scalp irritation and nausea after salon visits. Cases of acute renal injuries post-hair straightening have been reported, with biopsies showing calcium oxalate crystals in the kidneys. A clinical case involved a 26-year-old woman experiencing acute renal damage after hair straightening. The cream used contained glyoxylic acid, leading to oxalate crystal formation in the kidneys. The study on mice confirmed the nephrotoxic effect of glyoxylic acid.

Stats

"The results on mice are striking," study author Emmanuel Letavernier, MD, a nephrologist at Tenon Hospital in Paris, France, told the Medscape French edition.
"Glycolic acid does not pose a problem. Unlike glyoxylic acid, the application of glycolic acid on the skin of mice does not induce the formation of oxalate crystals in the kidneys, nor acute kidney failure."
"After passing through the epidermis, glyoxylic acid is rapidly converted in the blood to glyoxylate. In the liver and probably in other organs, glyoxylate is metabolized to become oxalate, which upon contact with calcium in the urine forms calcium oxalate crystals," explains the specialist.

Quotes

"The results on mice are striking."
"Glycolic acid does not pose a problem."

Key Insights Distilled From

Hair-Straightening Products Entail Acute Kidney Failure Risk

by Vincent Rich... at www.medscape.com 03-26-2024

https://www.medscape.com/viewarticle/hair-straightening-products-entail-acute-kidney-failure-risk-2024a10005oz

Deeper Inquiries

What are the potential long-term effects of using hair-straightening products with glyoxylic acid?

Using hair-straightening products containing glyoxylic acid can lead to acute kidney failure due to the accumulation of calcium oxalate crystals in the kidneys. The repeated exposure to glyoxylic acid can result in chronic renal failure, which is a major risk factor for long-term kidney damage. This can have serious implications on the individual's overall health and quality of life.

How can the beauty industry ensure the safety of cosmetic products containing potentially harmful substances?

The beauty industry can ensure the safety of cosmetic products containing potentially harmful substances by conducting thorough research and testing before introducing new ingredients into products. Regular monitoring and surveillance of adverse effects reported by consumers can help in identifying any safety concerns promptly. Implementing strict regulations and guidelines for ingredient usage, labeling, and product testing can also help in ensuring the safety of cosmetic products.

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