Core Concepts
Reproductive technology does not increase maternal CVD risk.
Abstract
The study focused on the impact of assisted reproductive technologies (ARTs) on the risk of cardiovascular disease (CVD) in women. Here is a breakdown of the key points:
Background:
ART usage is rising, but its association with CVD risk is unclear.
Previous studies showed weak evidence of increased stroke risk with ART.
Study Details:
2,496,441 women without preexisting CVD were included.
No significant difference in CVD risk between ART and non-ART groups.
Subgroup analyses showed varying risks for different CVD types.
Findings:
Frozen embryo transfer linked to higher CVD risk.
Intracytoplasmic sperm injection associated with lower CVD risk.
Authors suggest implications for individuals needing ART.
Limitations:
Study focused on middle-aged women.
Lack of data on socioeconomic factors and unsuccessful ART attempts.
Insufficient events for dose-response analysis.
Stats
After a median follow-up of 11 years, women using ART had no increased risk of CVD.
Rate of any CVD after 11 years was 153 per 100,000 person-years.
Risk of CVD did not significantly differ between ART and non-ART groups (AHR, 0.97; 95% CI, 0.91 – 1.02).
Higher risk of CVD with frozen embryo transfer (AHR, 1.24; 95% CI, 1.02 – 1.51).
Lower risk of CVD with intracytoplasmic sperm injection (AHR, 0.83; 95% CI, 0.74 – 0.94).
Quotes
"These findings may be reassuring to the increasing number of individuals who require assistance from ART to conceive."