Ventilatory Efficiency Impaired in Hypertension

Core Concepts

Patients with hypertension exhibit impaired ventilatory efficiency during exercise, indicating potential cardiac risk.

Abstract

TOPLINE: Hypertensive patients show elevated V E /VCO 2 slope, indicating ventilatory inefficiency during exercise. V E /VCO 2 slopes can help identify increased cardiac risk in hypertension. METHODOLOGY: Ventilatory efficiency is assessed using V E /VCO 2 relationship. V E /VCO 2 slope is elevated in heart failure but unclear in primary hypertension. Study included 55 hypertensive patients and 24 normotensive controls. Participants underwent cardiovascular pulmonary exercise tests on a bike ergometer. TAKEAWAY: Only 27.3% of hypertensive participants had a normal V E /VCO 2 slope. Hypertensive group had a higher V E /VCO 2 slope than controls. Peak breathing frequency was elevated in hypertensive individuals. IN PRACTICE: Noninvasive measures like V E /VCO 2 slope could aid in risk stratification and treatment decisions. SOURCE: Study conducted by Katrina Hope and colleagues, published in the Journal of the American Heart Association. LIMITATIONS: Further research is needed to understand the reasons behind the elevated V E /VCO 2 slope. DISCLOSURES: Study supported by various foundations, authors have no conflicts of interest.

Stats

Patients with hypertension have elevated V E /VCO 2 slope compared with normotensive controls. Peak breathing frequency was higher in hypertensive individuals. V E /VCO 2 slope was higher in untreated and treated-controlled hypertensive individuals.

Quotes

"Adding this noninvasive measure might be useful in the future for risk stratification and for making treatment decisions." - Authors

Key Insights Distilled From

Ventilatory Efficiency Impaired in Hypertension

by Pauline Ande... at www.medscape.com 06-28-2023

https://www.medscape.com/viewarticle/993828

Deeper Inquiries

What are the potential implications of using V E /VCO 2 slope in clinical practice

The use of V E /VCO 2 slope in clinical practice can have significant implications for risk stratification and treatment decisions in patients with hypertension. By assessing ventilatory efficiency during exercise, healthcare providers can identify individuals at increased cardiac risk, especially those with elevated V E /VCO 2 slopes. This noninvasive measure provides valuable information about how the cardiovascular and respiratory systems are functioning during physical activity, offering insights into the overall health status of patients. Incorporating V E /VCO 2 slope into clinical practice can help tailor treatment plans, monitor disease progression, and potentially improve outcomes for individuals with hypertension.

How might the findings of this study impact the management of hypertension

The findings of this study suggest that patients with hypertension exhibit impaired ventilatory efficiency during exercise, as indicated by elevated V E /VCO 2 slopes compared to normotensive individuals. This insight can have implications for the management of hypertension by highlighting the importance of assessing cardiovascular and respiratory function in these patients. Healthcare providers may consider incorporating V E /VCO 2 slope measurements into routine assessments for individuals with hypertension to better understand their cardiac risk profile and tailor treatment strategies accordingly. By identifying ventilatory inefficiency early on, clinicians can intervene proactively to optimize patient care and potentially improve outcomes in this population.

How can noninvasive measures like V E /VCO 2 slope contribute to overall patient care beyond cardiovascular health

Noninvasive measures like V E /VCO 2 slope can contribute significantly to overall patient care beyond cardiovascular health by providing valuable insights into respiratory function, exercise capacity, and metabolic efficiency. In addition to assessing cardiac risk in patients with hypertension, V E /VCO 2 slope can help healthcare providers evaluate pulmonary function, identify potential ventilation/perfusion abnormalities, and monitor changes in exercise tolerance over time. By incorporating noninvasive measures like V E /VCO 2 slope into clinical practice, clinicians can gain a more comprehensive understanding of patients' physiological responses to exercise and tailor interventions to improve overall health and well-being. This holistic approach to patient care can enhance treatment outcomes, promote preventive strategies, and support a more personalized approach to healthcare delivery.