Core Concepts
Vitamin D supplementation reduces relapse or death risk in p53-immunoreactive digestive tract cancer patients.
Abstract
The study analyzed the impact of vitamin D supplementation on patients with digestive tract cancer, specifically focusing on the p53-immunoreactive subgroup. Here are the key highlights and insights from the content:
Vitamin D supplementation reduced relapse or death risk by 73% in p53-immunoreactive patients.
5-year relapse-free survival was significantly higher in the vitamin D group compared to the placebo group.
No effect on survival outcomes was observed in the non-p53-immunoreactive subgroup.
The study suggests that vitamin D supplementation may be beneficial for reducing cancer risk and improving outcomes, particularly in patients with specific tumor biology.
Previous research has shown mixed evidence on the efficacy of vitamin D in reducing cancer mortality.
The study emphasizes the importance of developing cancer immunotherapy targeting mutated p53 proteins.
Stats
Vitamin D supplementation reduced the risk of relapse or death by 73% in the p53-immunoreactive subgroup.
5-year relapse-free survival was 81% in the vitamin D group vs 31% in the placebo group.
Vitamin D supplementation had no effect on survival outcomes in the non-p53-immunoreactive subgroup.
Post hoc analysis of the AMATERASU trial showed improved RFS in p53-positive digestive tract cancer patients with vitamin D supplementation.
Quotes
"These findings represent a 'game changer' for vitamin D and cancer." - Michael Holick, PhD, MD
"The main findings of this study were that daily supplementation of 2000 IU of vitamin D reduced the risk of relapse or death compared with placebo in the p53-immunoreactive subgroup." - Mitsuyoshi Urashima, MD, PhD, MPH