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Challenges in Cannabis Detection in Children's Drug Testing


Core Concepts
Cannabinoid confirmatory testing in children may yield false negatives due to reporting threshold changes.
Abstract
TOPLINE: Confirmatory testing may yield false negatives despite detectable cannabis metabolite concentrations. METHODOLOGY: Study focused on cannabinoid-positive drug screens at a pediatric hospital. False-positive rate increased with the higher reporting threshold. Majority of samples with negative LC-MS had detectable THC-COOH. TAKEAWAY: False-positive rate increased with the higher reporting threshold. Confirmatory testing may be relevant at lower concentrations for child protection. IN PRACTICE: Confirmatory testing should be used selectively and interpreted cautiously. Laboratories should report down to the limit of quantification on request. SOURCE: Study's corresponding author is Christopher J. Watson, MD. LIMITATIONS: Lack of information on the clinical context of patients undergoing drug screening. DISCLOSURES: Coauthor disclosed royalties from UpToDate outside of the study.
Stats
"The false-positive rate was 10.1% based on the 15 ng/mL threshold compared with 2% based on the 5 ng/mL limit of quantification." "About 81% of samples with negative LC-MS reports had detectable concentrations of THC-COOH."
Quotes
"Confirming THC-COOH in children's and adolescents' urine may be relevant at concentrations less than 15 ng/mL, particularly if child protection is pertinent." "Confirmatory testing should be reserved for select cases and must be interpreted with caution. Laboratories should report down to the limit of quantification on request."

Key Insights Distilled From

by Jake Remaly at www.medscape.com 11-27-2023

https://www.medscape.com/viewarticle/998780
New Drug Reporting Limit May Overlook Cannabis in Kids

Deeper Inquiries

How can reporting thresholds for cannabis metabolites be standardized across different laboratories?

Standardizing reporting thresholds for cannabis metabolites across different laboratories can be achieved through the establishment of universal guidelines or regulations. Regulatory bodies or professional organizations in the medical field can develop standardized protocols for drug testing, including specific thresholds for metabolite concentrations. These guidelines should be based on scientific evidence, taking into account factors such as sensitivity and specificity of the testing methods. Regular calibration and proficiency testing programs can also help ensure consistency in reporting thresholds among laboratories.

What are the ethical considerations when conducting drug testing on children?

When conducting drug testing on children, several ethical considerations must be taken into account. Firstly, informed consent must be obtained from the child's legal guardian, ensuring that they understand the purpose, risks, and benefits of the testing. Confidentiality and privacy of the child's medical information should be maintained throughout the testing process. It is essential to consider the potential impact of the test results on the child's well-being and future, especially in cases where child protection issues may arise. Additionally, healthcare providers should prioritize the best interests of the child and ensure that the testing is conducted in a non-coercive and supportive manner.

How can advancements in technology improve the accuracy of confirmatory drug testing in pediatric patients?

Advancements in technology can significantly enhance the accuracy of confirmatory drug testing in pediatric patients. The use of liquid chromatography–mass spectrometry (LC-MS) allows for more precise and reliable detection of cannabis metabolites in urine samples, reducing the likelihood of false-negative results. Automation and robotics in laboratory processes can streamline testing procedures, minimizing human error and improving overall accuracy. Furthermore, the development of more sensitive and specific testing methods, such as high-performance liquid chromatography (HPLC) or gas chromatography–mass spectrometry (GC-MS), can increase the detection capabilities of drug testing, especially in cases where low concentrations of metabolites need to be identified. Continuous research and innovation in technology will continue to advance the accuracy and efficiency of confirmatory drug testing in pediatric patients.
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