Core Concepts
Eosinopenia and low EC/NC ratio are indicators of infection in tocilizumab users.
Abstract
TOPLINE:
Eosinopenia and low EC/NC ratio indicate infection in tocilizumab users.
METHODOLOGY:
Data from 163 tocilizumab-treated patients with inflammatory diseases reviewed.
41 patients had unscheduled hospitalizations for suspected infections.
Median age of patients was 59 years, 83% were female.
TAKEAWAY:
49% of hospitalized patients had infectious diseases.
Common infections: pneumonia (30%), joint/bone infections (25%), GI tract infections (15%).
Lower EC in infected patients compared to non-infected.
Lower EC/NC ratio in infected patients.
IN PRACTICE:
Parameters like EC and EC/NC ratio can aid in infection screening.
SOURCE:
Lead author: Audrey Glatre, MD, University Hospital Centre Reims, France.
Published in RMD Open on February 9.
LIMITATIONS:
Retrospective, observational design.
Small study population.
Data from a single center.
DISCLOSURES:
Study had no external funding.
Researchers had no financial conflicts.
Stats
Eosinopenia and low EC/NC ratio are indicators of infection for tocilizumab users.
Infectious diseases diagnosed in 49% of hospitalized patients.
Common infections: pneumonia (30%), joint/bone infections (25%), GI tract infections (15%).
Median EC significantly lower in infected patients (0.06 g/L vs 0.20 g/L).
Median EC/NC ratio significantly lower in infected patients (6.54 vs 48.50).
Quotes
"This original study suggests that all those easily available parameters should be used to maximize [sensitivity] in the screening of infection in patients undergoing treatment with IL-6 pathway antagonists." - Researchers