Core Concepts
Elderly individuals with detectable fecal hemoglobin (f-Hb) concentration in a negative fecal immunochemical test (FIT) are at significantly higher risk of developing colorectal cancer (CRC).
Stats
Per 10,000 negative FIT tests, the interval CRC risk was 21.6 overall; in those with a prior f-HB concentration > 0 μg/g, it was 65.8 (P < .001).
In those with a prior concentration > 0 μg/g, the hazard ratio for an interval CRC was 4.86 and the odds ratio of advanced stage CRC was 1.45, compared with those without.
Quotes
"A risk-stratified upper age limit in CRC screening based on prior f-Hb concentration may prevent CRC cases and CRC-related morbidity."