Core Concepts
Survival outcomes in gastric cancer vary by race and ethnicity.
Abstract
The content discusses the survival differences in US patients with resected stage II or III gastric cancer based on race and ethnicity.
TOPLINE:
- Asian and Hispanic patients show better overall survival than White and Black patients.
METHODOLOGY:
- Researchers analyzed survival outcomes by race, ethnicity, treatment type, and other factors.
- Retrospective analysis included 6938 patients with gastric adenocarcinoma.
- Factors compared included race, ethnicity, surgical margins, lymph nodes, and treatment modality.
TAKEAWAY:
- Perioperative chemotherapy linked to improved overall survival.
- Surgical resection alone, positive lymph nodes, and positive surgical margins decrease overall survival.
- Asian and Hispanic patients have better overall survival than White patients.
IN PRACTICE:
- Asian and Hispanic race and ethnicity associated with improved overall survival.
- Asian and Black patients respond more favorably to neoadjuvant therapy.
SOURCE:
- Research led by Steve Kwon, MD, MPH, published in JAMA Network Open.
LIMITATIONS:
- Findings may be limited by the database used.
DISCLOSURES:
- No funding or relevant financial relationships declared.
Stats
"Overall survival among US patients with resected stage II or III gastric cancer differs by race and ethnicity, with Asian and Hispanic patients demonstrating better overall survival than White and Black patients."
"Just over half of the patients (53.6%) were White, 24.3% were Black, 17.8% were Hispanic, 15.8% were Asian, and 2.6% were other race or ethnicity."
"Perioperative chemotherapy was associated with improved overall survival (hazard ratio [HR], 0.79)."
"Asian and Hispanic patients had significantly better overall survival (HR, 0.64 and 0.77, respectively) than White patients."
"Black patients who received neoadjuvant therapy had better overall survival than White patients (HR, 0.78)."
Quotes
"Asian and Hispanic race and ethnicity were independently associated with improved [overall survival] compared with Black and White race."