Core Concepts
Proteins related to growth hormone activity can serve as risk markers for type 2 diabetes in adolescents.
Abstract
The content discusses the significant links between plasma levels of proteins involved in growth hormone activity and the controllability of type 2 diabetes in adolescents. Key points include:
- Dr. Chang Lu's research on growth hormone mediators and their association with glycemic failure in youth with type 2 diabetes.
- Potential applications of these findings in predicting type 2 diabetes onset and identifying at-risk adolescents for more intervention.
- The impact of growth hormone changes during puberty on the aggressive course of type 2 diabetes.
- Analysis of growth hormone-related peptides in adolescents with type 2 diabetes and their correlation with glycemic failure.
- Suggestions for future studies to explore the relationship between growth hormone signaling and glycemic control in children and adolescents with prediabetes and obesity.
Stats
"Plasma levels of three proteins involved in growth hormone activity showed significant links to the controllability of type 2 diabetes in adolescents."
"The primary outcome showed a 39%-52% incidence of failure during 5 years of follow-up depending on the specific treatments the study participants received."
"An increase in insulin-like growth factor-1 significantly linked with a reduced incidence of glycemic failure and improved glycemia and beta-cell function."
"Increasing plasma levels of growth hormone receptor significantly linked with an increased rate of glycemic failure, hyperglycemia, insulin resistance, and diminished beta-cell function."
"An increase in insulin-like growth factor binding protein-1 significantly linked with glycemic failure and hyperglycemia at 36 months, and with higher insulin sensitivity at baseline."
Quotes
"Plasma growth hormone mediators are associated with glycemic failure in youth with type 2 diabetes."
"Puberty-associated changes in growth hormone and related peptides could be why type 2 diabetes starts during puberty."
"The increase in growth hormone during puberty can unmask a physiologic and genetic predisposition to developing type 2 diabetes."