Core Concepts
Imaging agent pafolacianine significantly aids in identifying cancerous tissue during lung cancer surgery.
Abstract
The data showcases the utility of the imaging agent pafolacianine (Cytalux) in lung cancer surgery, leading to clinically significant changes in over half of surgeries. The agent binds to folate receptors in pulmonary malignancies, causing them to fluoresce under near-infrared light, aiding surgeons in more thorough resections. The approval was based on the ELUCIDATE trial, showing promising results in detecting primary tumors, occult lesions, and surgical margins. Adverse events were generally mild, with nausea being the most common. Further research is needed to confirm improvements in disease-free survival and the agent's potential in early-stage lung cancers.
Stats
Pafolacianine illuminated one or more clinically significant events in 53 surgical patients (53%).
The estimated sensitivity for detecting cancerous tissue was 76.9%; the false positive rate was 25.9%.
Most common adverse events were nausea (13%), vomiting (5%), and abdominal pain (2%).
Quotes
"Our research confirmed that Cytalux helps surgeons more easily visualize lesions and detect additional cancer at one of the most critical moments — during their operation." - Inderpal Sarkaria, MD