Core Concepts
LT3 may be beneficial in hypothyroidism treatment.
Abstract
The Joint British Thyroid Association/Society recommends considering liothyronine (LT3) in combination with levothyroxine (LT4) for hypothyroid patients with persistent symptoms. Despite mixed evidence, the debate over LT3/LT4 therapy continues. The consensus statement outlines key conditions for considering combination therapy and emphasizes the importance of clinical judgment in prescribing LT3. Alternative treatments like desiccated thyroid extract are also discussed.
Highlights
- LT3 may be useful in some hypothyroid patients with persistent symptoms.
- Debate over LT3/LT4 therapy persists despite inconclusive evidence.
- Guidelines outline conditions for considering combination therapy.
- Clinical judgment is crucial in prescribing LT3.
- Alternative treatments like desiccated thyroid extract are mentioned.
Insights
- Majority of hypothyroid patients respond well to levothyroxine.
- Debate over LT3/LT4 therapy has lasted over two decades.
- Patients may experience ongoing symptoms despite biochemical normalization.
- Alternative treatments like desiccated thyroid extract are considered.
- Clinical judgment is emphasized in prescribing LT3.
Stats
"For the small minority of patients who remain symptomatic despite adequate biochemical replacement with levothyroxine, a trial of liothyronine/levothyroxine combination therapy under specialist supervision may be appropriate."
"The scientific community is divided as to whether or not the LT4/LT3 combination therapy has any value whatsoever."
"In reality, many patients with subclinical hypothyroidism [TSH 5-10 mU/L] are now treated with levothyroxine, fueling a rise in its use."
Quotes
"The scientific community is divided as to whether or not the LT4/LT3 combination therapy has any value whatsoever."
"I welcome this joint statement very much because it provides guidance, especially for clinicians, on a hotly debated issue."
"In reality, many patients with subclinical hypothyroidism [TSH 5-10 mU/L] are now treated with levothyroxine, fueling a rise in its use."