Core Concepts
Specific bacterial strains show promise in regulating gut inflammation in UC patients.
Abstract
Introduction
Eight live bacterial strains identified to regulate gut microbiome in UC patients.
MB310, a biotherapeutic product, to undergo clinical trial for UC treatment.
Research Findings
Specific bacterial strains elevated in UC patients benefiting from FMT.
Anti-inflammatory effects observed in lab studies with immune cells.
Phase 1b trial COMPOSER-1 to assess MB310 in 30 UC patients.
Calming Inflammation
Research focused on bacterial species correlating with UC clinical outcomes.
Pooled donor FMT group showed higher success rates in UC remission.
Precision microbiome analysis led to identification of eight key bacterial species.
Therapeutic Development
Eight bacterial strains cultured into a custom capsule for testing.
MB310 showed positive effects on barrier integrity and inflammation.
Strains regulated T-cells directly or via metabolites.
Future Directions
More trials needed before clinical use of biotherapeutic.
Focus on functionally active bacterial strains for optimal treatment.
Industrializing the process to produce strains at scale.
Stats
"Results indicated that the group receiving the pooled donor FMT showed a 32% success rate with respect to the primary outcome compared with only 9% of the control group," said Carter.
Quotes
"Many more trials need to be done before we see this enter the clinic, but this is moving in the right direction," Kirchgesner noted.
"The researchers want to identify which bacterial strains will impact the effectiveness in patients, and to select for these strains before industrializing the process and producing them at the optimal strength, at scale," Kirchgesner said.