Switching From IV to Oral Antibiotics: Study Shows Safety

Core Concepts

Oral antibiotics are a safe alternative to prolonged IV antibiotics for uncomplicated gram-negative bacteremia.

Abstract

TOPLINE: Oral antibiotics may be a safe alternative to prolonged IV antibiotics. METHODOLOGY: Study analyzed data from 914 adults with gram-negative bacteremia in Denmark. Patients switched to oral antibiotics within 4 days showed lower mortality rates. TAKEAWAY: Patients on oral antibiotics had a lower risk of death compared to IV treatment. IN PRACTICE: Mortality rates were comparable between early stepdown and prolonged IV treatment. SOURCE: Study led by Sandra Tingsgård, MD, at Copenhagen University Hospital. LIMITATIONS: Data based on electronic health records, limited cases of multidrug-resistant infections. DISCLOSURES: Authors report no disclosures or funding sources.

Stats

Overall, 14.3% of patients on prolonged IV treatment died. Patients switched to oral antibiotics had a 22% lower risk of death within 90 days. Patients on oral antibiotics had a 1% lower odds of dying within 90 days.

Quotes

"These findings suggest that the mortality associated with early antibiotic stepdown treatment is comparable to that associated with receiving prolonged IV antibiotic treatment for individuals with uncomplicated gram-negative bacteremia." - Study Authors

Key Insights Distilled From

Switching From IV to Oral Antibiotics Safe, Study Shows

by Brittany at www.medscape.com 01-30-2024

https://www.medscape.com/viewarticle/switching-iv-oral-antibiotics-safe-patients-study-shows-2024a100023p

Deeper Inquiries

How can healthcare systems implement the findings of this study effectively?

Healthcare systems can implement the findings of this study effectively by incorporating protocols that allow for the timely assessment of patients with uncomplicated gram-negative bacteremia to determine if they are suitable candidates for switching from IV to oral antibiotics. This may involve establishing clear criteria for identifying patients who can safely transition to oral antibiotics, ensuring proper monitoring post-transition, and providing education to healthcare providers on the benefits and risks associated with this approach. Additionally, healthcare systems can update their guidelines and protocols based on the study's results to optimize patient outcomes and potentially reduce the risk of secondary infections associated with prolonged IV antibiotic use.

What are potential drawbacks of switching from IV to oral antibiotics in certain cases?

While switching from IV to oral antibiotics may offer benefits such as reduced mortality rates and lower risks of secondary infections, there are potential drawbacks to consider in certain cases. One drawback is the possibility of decreased bioavailability of oral antibiotics compared to IV administration, which could impact the effectiveness of treatment, especially in patients with severe infections or compromised gastrointestinal function. Additionally, some patients may have difficulty tolerating oral antibiotics due to gastrointestinal side effects, which could lead to non-adherence to the prescribed treatment regimen. In cases where rapid and high antibiotic concentrations are required, such as in critically ill patients, oral antibiotics may not achieve the desired therapeutic levels as quickly as IV antibiotics, potentially delaying the resolution of the infection.

How can patient preferences influence the choice between IV and oral antibiotic treatment?

Patient preferences can play a significant role in the choice between IV and oral antibiotic treatment. Some patients may have a strong preference for oral antibiotics due to the convenience and flexibility they offer, especially if it allows for outpatient treatment or shorter hospital stays. On the other hand, patients who are more comfortable with IV administration or have concerns about the efficacy of oral antibiotics may prefer to continue receiving antibiotics intravenously. Healthcare providers should engage in shared decision-making with patients, taking into account their preferences, lifestyle factors, and medical history when determining the most appropriate route of antibiotic administration. By involving patients in the decision-making process, healthcare providers can ensure that treatment plans align with patients' values and preferences, ultimately improving treatment adherence and outcomes.