Core Concepts
Thyroid hormone therapy in older patients may increase the risk of cognitive disorders.
Abstract
Patients aged 65 and older receiving thyroid hormone therapy with low thyrotropin levels face an increased risk of dementia and cognitive issues. The study analyzed over 65,000 patients, highlighting the association between thyrotoxicosis and incident cognitive disorders. Women were more prone to low thyrotropin levels and overtreatment. Primary care physicians are advised to be cautious in prescribing thyroid hormone therapy to older patients to avoid overtreatment and potential cognitive disorders. The study emphasizes the importance of considering the risks versus benefits of thyroid hormone therapy in older adults.
Stats
Patients with thyrotoxicosis had a higher likelihood of incident cognitive disorder (adjusted hazard ratio (aHR), 1.39; 95% CI, 1.18 - 1.64; P < .001).
Exogenous thyrotoxicosis was a significant risk factor (aHR, 1.34: 95% CI, 1.10 - 1.63; P = .003).
7.2% of patients received a new cognitive disorder diagnosis during the follow-up period.
Quotes
"There's so much gray zone here." - Jean Chen