The STEP-HFpEF trial analyzed the impact of weight loss on outcomes in patients receiving weekly semaglutide treatment. Weight loss was found to be a major factor in improving symptoms, physical limitations, exercise capacity, and inflammation. The study highlighted the importance of medically induced weight loss in managing patients with obesity-phenotype HFpEF. Key findings included significant improvements in the Kansas City Cardiomyopathy Questionnaire Clinical Summary Score, 6-minute walk distance, and C-reactive protein levels with weight loss. The study also indicated that weight loss was a good surrogate marker for the range of effects from treatment with semaglutide, a GLP-1 receptor agonist.
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by Mitchel L. Z... at www.medscape.com 08-28-2023
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