Core Concepts
Zerlasiran siRNA significantly reduces Lp(a) levels by 90% in high-risk patients.
Abstract
Silence Therapeutics released positive 36-week data from the phase 2 study of zerlasiran, an siRNA agent targeting Lp(a) reduction. The study demonstrated a substantial decrease in Lp(a) levels compared to placebo, with promising results in high-risk patients. Zerlasiran, previously known as SLN360, acts by silencing the LPA gene, a key factor in Lp(a) synthesis. The ongoing trial, ALPACAR-360, enrolled 178 high-risk patients and showed a median reduction of over 90% in Lp(a) levels at week 36. The study continues to evaluate secondary endpoints and lipid effects, with plans to report 48-week data soon.
Stats
Zerlasiran showed a median reduction in Lp(a) of ≥ 90% at week 36.
Median baseline Lp(a) levels were approximately 215 nmol/L.
The drug was administered at 300 mg every 16 or 24 weeks or at 450 mg every 24 weeks.
Quotes
"Zerlasiran demonstrates a highly significant reduction in Lp(a) levels compared to placebo."
"Elevated Lp(a) levels pose a genetic risk for cardiovascular disease."