Core Concepts
Ikaros is crucial for establishing the Treg gene expression program, cooperating with Foxp3 to regulate inflammatory responses and immune tolerance.
Stats
A total of 661 genes were differentially expressed in Ikzf1 cko Treg...
Loss of Ikaros results in up-regulation of at least 12 factors that negatively regulate Treg function...
Quotes
"Ikaros plays a crucial role in establishing the normal landscape of enhancer activity..."