Core Concepts
An explainable and conformal AI model can accurately detect temporomandibular joint involvement in children with juvenile idiopathic arthritis based on clinical examinations alone.
Abstract
This study developed an explainable artificial intelligence (AI) model to assess temporomandibular joint (TMJ) involvement in children under 16 years old who suffer from juvenile idiopathic arthritis (JIA). The model was trained using a Random Forest algorithm on a dataset of 6,154 longitudinal clinical examinations of 1,035 pediatric patients.
The key findings are:
Using a "Temporal Segmentation" strategy, the model can classify patients within two years of their first examination as having TMJ involvement with a precision of 0.86 and a sensitivity of 0.7. This is a significant improvement over previous attempts using only clinical examinations.
The model's explainability, obtained through Shapley Additive exPlanations (SHAP), identifies the most important clinical features for predicting TMJ involvement, such as lateral translation, protrusion, and asymmetry of the jaw.
Incorporating historical clinical data through a "Lagged Features" strategy slightly improves the model's sensitivity by 2.5%, from 0.8 to 0.82, compared to using only the current examination data.
The results demonstrate the potential of an AI-based decision support tool to enhance timely diagnosis of TMJ involvement in children with JIA, which can lead to improved treatment planning and outcomes. The explainable nature of the model also helps clinicians understand and trust the AI's predictions.
Stats
The dataset contains 6,154 longitudinal records of 1,035 pediatric patients (<16 years old) over a 25-year period.
The model was trained on 2,682 examinations recorded in the first two years of a patient's first visit.
Quotes
"Early diagnosis and management can prevent some of the physical and psychological consequences that come with JIA, and lead to an anticipated better outcome for the child and their family."
"The results show promise for an AI model in the assessment of TMJ involvement in children and as a decision support tool for clinicians."