Core Concepts
The author presents a miniaturized microfluidic device for wirelessly controlled ultrafast active drug delivery, driven by an oscillating solid-liquid interface.
Abstract
The content discusses the development of a novel drug delivery system that utilizes acoustic streaming to achieve on-demand drug release. The system is miniaturized, wirelessly controlled, and demonstrates ultrafast response times. It offers precise control over drug release rates and shows potential for long-term controlled drug delivery in chronic diseases.
The article highlights the limitations of traditional passive drug delivery systems and compares them with the active acoustofluidic method presented. The technology leverages gigahertz resonators to generate high-speed acoustic streaming, enabling rapid and controllable drug release. Experimental results demonstrate the system's stability, reliability, and potential for implantable applications.
Key points include the fabrication process of the device, theoretical simulations of the drug delivery process, characterization of membrane deformation, wireless control mechanisms using magnetic fields, and long-term testing results showcasing negligible leakage during off-states and precise drug release during on-states.
Overall, the acoustofluidic drug delivery system represents a significant advancement in targeted and controlled medication administration for chronic diseases.
Stats
High-speed microscopy reveals fast valve response time of 1 ms.
Released drug amount correlates linearly with working time and electric power applied.
Wireless control via magnetic field triggers stable output over two weeks.
Quotes
"The rapid-response of the resonator enables ultrafast model drug delivery on the order of 1 ms."
"The device can be wirelessly controlled by an external magnetic field."
"Long-term testing demonstrated negligible leakage at off-state periods."