Core Concepts
An advanced computational model simulates colon motility after laser tissue soldering, emphasizing the importance of material properties and couplings for physiological muscular contractions.
Abstract
The study introduces a multi-physics model for in silico colon motility, integrating electromechanics and electrophysiology. It proposes a theoretical framework with detailed microstructural and electrophysiological models to simulate laser tissue soldering effects on colon motility. The computational framework accurately reproduces manometric traces observed clinically in human patients, showcasing high or low-amplitude propagation contractions. Various constitutive models are proposed to capture the complex behavior of gastrointestinal tissues. The study highlights the significance of developing a digital twin model to predict organ responses post-interventions accurately.
Stats
"The active strain approach was adopted to describe tissue electromechanics."
"In clinical practice, HRM involves inserting a catheter with 36 pressure transducers spaced 1 cm or 2 cm apart."
"Several electrical models have been proposed in the literature to reproduce the complex spatiotemporal phenomenology of gastrointestinal excitation."
"The GI wall is a complex multilayered structure comprising serosa, muscularis externa, Auerbach’s plexus, submucosa, and mucosa."
"Exponential anisotropic constitutive laws have been shown to characterize well the mechanical behavior of several intact GI segments."
Quotes
"The proposed theoretical framework comprises three main elements: a microstructural material model describing intestine wall geometry and composition of reinforcing fibers..."
"Colon motility after laser tissue soldering demonstrates that material properties and couplings of the deposited tissue are critical to reproducing a physiological muscular contraction..."
"Moreover, bonding requires great dexterity on the part of the clinician and the robots..."