The TAME study aimed to assess the impact of mild hypercapnia on comatose patients post-resuscitation from out-of-hospital cardiac arrest. The study did not show any improvement in neurologic, functional outcomes, or quality of life at 6 months. However, it was noted that elevated CO2 levels were not associated with worse outcomes. The trial involved 1700 adults with coma who were randomly assigned to receive either mild hypercapnia or normocapnia for 24 hours. Results indicated no significant difference in outcomes between the two groups. Safety concerns regarding hypercapnia were addressed, with no increase in adverse events reported. Further analyses are planned to explore potential prognostic markers and individual patient responses to hypercapnia. The study also established a network for future trials in this patient population.
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by Sue Hughes at www.medscape.com 06-19-2023
https://www.medscape.com/viewarticle/993372Deeper Inquiries