Core Concepts
Immunoglobulins play a crucial role in evaluating disease activity and predicting recurrence in Takayasu arteritis patients.
Abstract
Standalone Note here
Abstract and Introduction
Investigated correlation between immunoglobulins and disease activity in Takayasu arteritis (TAK).
Elevated immunoglobulins linked to higher disease activity and inflammatory factors.
CD138 + plasma cells increased in TAK patients compared to atherosclerotic patients.
Changes in IgG correlated with CRP and ESR levels.
Elevated immunoglobulins associated with 1-year recurrence in TAK patients in remission.
Introduction
Takayasu arteritis (TAK) is a chronic vasculitis primarily affecting the aorta and its branches.
Cell-mediated autoimmunity is closely linked to TAK pathogenesis.
Evidence suggests involvement of humoral immunity in TAK, despite past controversies.
B cells play a significant role in TAK pathogenesis, supported by various studies.
Stats
"Disease activity and inflammatory factors were significantly higher in the group with elevated immunoglobulins than in the normal group [NIH (3.0 vs. 2.0, P = 0.001), ITAS-A (9.0 vs. 7.0, P = 0.006)]."
"Changes in IgG correlated well with CRP and ESR [CRP (r = 0.40, P = 0.027), ESR (r = 0.64, P < 0.001)]."
"For patients with TAK in remission, elevated immunoglobulins was associated with 1-year recurrence [OR95%, CI: 2.37 (1.03, 5.47), P = 0.042]."
Quotes
"Immunoglobulins is of clinical value in evaluating disease activity in TAK patients."
"Moreover, the dynamic changes of IgG were correlated with the changes in inflammatory indicators in TAK patients."