Core Concepts
High-quality preoperative MRI combined with postoperative analysis can identify early breast cancer patients who can safely skip radiation therapy.
Stats
Omitting radiation therapy after breast-conserving surgery led to a very low local recurrence rate (1%) at 5 years.
Preoperative MRI detected 61 malignant occult lesions separate from the index cancer in 48 patients (11%) of the total cohort.
The ipsilateral invasive recurrence rate in the group that omitted radiation was 1.0% at 5 years.
Quotes
"The hypothesis was that less treatment [would] lead to more fear of cancer recurrence" - Gregory Bruce Mann
"If the patient got the impression that the doctor wasn't worried about recurrence, then the patient wasn't worried." - Gregory Bruce Mann
"PROSPECT adds laudably to the tradition of personalized medicine." - Lior Z. Braunstein