Core Concepts
PET scans at GCA diagnosis can predict aneurysm risk.
Abstract
In a study focusing on giant cell arteritis (GCA), PET scans were utilized as both a diagnostic and prognostic tool. The study followed over 100 GCA patients who underwent 18F-fluorodeoxyglucose (FDG) PET imaging, revealing that those with elevated FDG uptake at diagnosis were more prone to developing thoracic aortic aneurysms. The research, led by Lien Moreel, MD, from the University Hospitals Leuven, Belgium, emphasizes the potential of PET imaging at diagnosis to estimate the future risk of aortic aneurysm formation in GCA patients. The study, published in Annals of Internal Medicine, highlights the importance of early PET scans for diagnostic and prognostic purposes in GCA patients. The positive PET scan results were associated with a higher risk of incident thoracic aortic aneurysms, indicating the predictive value of PET imaging in assessing aortic complications in GCA patients. The study suggests the need for further research to establish clear guidelines for the follow-up and monitoring of GCA patients with positive PET scan results.
Stats
"In the study, Moreel and colleagues prospectively followed 106 individuals diagnosed with GCA who received FDG-PET within 3 days after starting glucocorticoids."
"A PET scan was considered positive with an FDG uptake of grade 2 or higher in any of seven vascular regions."
"The risk of incident thoracic aortic aneurysms was calculated to be 10 times higher in patients with positive PET scans."
Quotes
"PET-CT has an excellent diagnostic accuracy for the diagnosis of GCA, certainly if both extracranial and intracranial vessels were assessed." - Lien Moreel, MD
"There are no clear guidelines, but most clinicians who take care of patients with GCA do obtain imaging periodically." - Dr. Kenneth Warrington