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Understanding Biologic Adjuvants for Ankle Cartilage Injuries


Core Concepts
Biologic adjuvants show promise in treating ankle cartilage injuries.
Abstract
Abstract: Osteochondral lesions of the talus in the ankle can lead to early-onset osteoarthritis if untreated. Surgical strategies are often necessary due to the limited healing capacity of avascular cartilage. Fibrocartilage is produced instead of native hyaline cartilage, impacting mechanical properties. Biologic augmentation, such as bone marrow aspirate and platelet-rich plasma, has shown potential in improving cartilage healing. Introduction: Ankle cartilage lesions can progress to arthritis and chronic pain if left untreated. A significant percentage of patients with ankle sprains or fractures have cartilage injuries. Conservative treatments include anti-inflammatory medications and activity modification. Surgical interventions may be necessary for patients with persistent symptoms. Various reparative and arthroplasty strategies are used for chondral injuries. Biologics like concentrated bone marrow aspirate and hyaluronic acid are commonly used as adjuncts to regenerative interventions. Mesenchymal stem cells play a crucial role in cartilage repair through their secretome.
Stats
"It has been estimated that up to 50% of patients who sustain an ankle sprain and up to 88% of patients who sustain an ankle fracture have a concomitant cartilage injury." "The most commonly used biologic adjuncts include concentrated bone marrow aspirate (CBMA), platelet-rich plasma (PRP), hyaluronic acid (HA), and micronized adipose tissue (MAT)."
Quotes
"The secretome's immunomodulatory, anti-apoptotic, angiogenic, and anti-fibrotic effects are critical in maintaining joint homeostasis." "Historically, the elements required for cartilage regeneration included growth factors, a proper scaffold, and mesenchymal stem cells (MSCs)."

Key Insights Distilled From

by Arianna L. G... at www.medscape.com 08-22-2023

http://www.medscape.com/viewarticle/994560
Rethinking Cartilage Lesions of the Ankle

Deeper Inquiries

How do biologic adjuvants compare to traditional surgical interventions for ankle cartilage injuries?

Biologic adjuvants offer a promising alternative or adjunct to traditional surgical interventions for ankle cartilage injuries. While traditional surgical approaches like bone marrow stimulation or autologous chondrocyte implantation aim to repair the damaged cartilage, they often result in the formation of fibrocartilage with inferior mechanical properties. In contrast, biologic adjuvants such as concentrated bone marrow aspirate, platelet-rich plasma, hyaluronic acid, and micronized adipose tissue have been shown to enhance the healing process by providing growth factors, scaffolding, and MSCs. These biologics can promote the formation of more hyaline-like cartilage, which is closer to the native tissue, leading to improved mechanical and tribological properties in the long term.

What are the potential drawbacks or limitations of using biologics in cartilage healing?

While biologic adjuvants show promise in cartilage healing, there are potential drawbacks and limitations to consider. One limitation is the variability in the composition and quality of biologics, which can affect their efficacy. The cost of biologic treatments can also be a limiting factor for some patients, as they may not be covered by insurance and can be expensive out-of-pocket. Additionally, the regulatory landscape for biologics is still evolving, leading to uncertainties in their standardization and approval. There is also a need for more long-term studies to assess the durability and effectiveness of biologic treatments compared to traditional surgical interventions. Furthermore, the optimal dosing, timing, and delivery methods of biologics in cartilage healing are still areas of ongoing research and refinement.

How can the understanding of MSCs and their secretome impact future treatments for joint injuries?

The understanding of MSCs and their secretome has the potential to revolutionize future treatments for joint injuries. Rather than directly differentiating into chondrocytes, MSCs are now known to play a crucial role in producing a secretome that exerts immunomodulatory, anti-apoptotic, angiogenic, and anti-fibrotic effects. This secretome acts as a paracrine signaling apparatus that supports joint homeostasis and can stimulate the growth and differentiation of local host stem cells. By harnessing the regenerative properties of MSCs and their secretome, future treatments for joint injuries may focus on enhancing the body's natural healing processes, promoting tissue repair, and potentially reducing the need for invasive surgical interventions. This paradigm shift towards a more biologically driven approach holds great promise for improving outcomes and reducing the long-term impact of joint injuries.
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