Core Concepts
Antibiotic exposure does not significantly affect bacterial yield in bone biopsy cultures.
Abstract
Abstract:
Antibiotics before bone biopsy are believed to affect culture results.
Study evaluated bacterial yield in DFO microbiology specimens.
No significant difference in culture yield between patients who received antibiotics and those who did not.
Duration of antibiotic use did not impact bacterial yield.
Introduction:
Common belief that antibiotics prior to bone biopsy render culture results unreliable.
Negative culture results may be disregarded due to antibiotic exposure.
Study aimed to evaluate the effect of antibiotics on bacterial pathogen identification in DFO patients.
Null hypothesis: bacterial culture identification would be the same regardless of antibiotic exposure.
Stats
The proportion of bone biopsies with positive bacterial cultures was 77.9% in patients who received antibiotics and 85.7% in patients who did not (P = .58).