Core Concepts
Individuals respond differently to BP meds, personalized therapy may be beneficial.
Abstract
The study highlights substantial variation in blood pressure response to antihypertensive medications, emphasizing the potential for personalized therapy. Key points include:
- Only 1 in 4 women and 1 in 5 men with hypertension reach treatment targets.
- Personalized treatment led to a 4.4 mm Hg lower systolic blood pressure compared to random drug choice.
- Identifying the optimal drug for each patient is crucial for effective treatment.
- Phenotypic characteristics or direct measurement of responses can aid in personalizing therapy.
- Nonadherence to antihypertensives is a significant issue that personalized therapy may address.
- The study provides proof-of-principle for personalized antihypertensive drug therapy.
Stats
"We found that using the optimal antihypertensive drug for a particular patient resulted in an average of a 4.4 mm Hg greater reduction of blood pressure compared with a random choice of the other drugs."
"Overall, personalized treatment using the optimal single-drug therapy led to a 4.4 mm Hg lower systolic blood pressure in the trial population than a random choice of any of the other drug classes."
"Taking into consideration that lisinopril was found to be on average the most efficacious of the drugs at the selected doses, personalized treatment compared with lisinopril still led to a 3.1 mm Hg improvement in systolic blood pressure."
Quotes
"We found that using the optimal antihypertensive drug for a particular patient resulted in an average of a 4.4 mm Hg greater reduction of blood pressure compared with a random choice of the other drugs."
"These preliminary findings suggest that some people may be better treated with one antihypertensive drug rather than another. This is opening up the field of hypertension for personalized medicine."
"The million-dollar question is how we identify the best drug for each individual patient."