Amyotrophic lateral sclerosis (ALS) affects skeletal muscles, but extraocular muscles (EOMs) are spared. EOM satellite cells (SCs) show unique activation patterns. Cxcl12 expression is higher in EOM SCs, promoting axon extension. Butyrate treatment preserves NMJ integrity and SC renewability. Transcriptomic differences suggest therapeutic targets for ALS.
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by Li,A., Yi,J.... at www.biorxiv.org 02-13-2023
https://www.biorxiv.org/content/10.1101/2023.02.12.528218v4Deeper Inquiries