Core Concepts
Opposing and complementary contributions of striatal pathways vary by compartment and context.
Abstract
The content explores the contributions of direct (dSPNs) and indirect (iSPNs) pathways in the basal ganglia to action selection and locomotion. Key highlights include:
- Different effects of dSPNs or iSPNs modulation on real-time place preference in DMS vs. DLS.
- Opposing contributions of dSPNs or iSPNs during action selection in DMS but not DLS.
- Activation or inhibition effects on reward-seeking displacements differ between compartments.
- Differential outcomes of pathway modulation on spontaneous displacements based on compartment.
Stats
"Animals that received self-stimulation in dSPNs, either in the DMS or DLS, spent more time in the quadrant paired with self-stimulation."
"Inhibition of either pathway in the DLS decreases while only iSPNs inhibition in the DMS facilitates these displacements."
Quotes
"Activation of dSPNs or iSPNs evokes preference or avoidance respectively."
"Self-modulation of dSPNs during action selection supports opposite and complementary contributions."
"Inhibition of dSPNs slows displacement to reach a goal, but increases locomotion without a goal."