Core Concepts
Adult-born granule cells in the CA2 region of the hippocampus play a crucial role in the retrieval of remote developmental memories of the mother in adult mice.
Abstract
Abstract
Adult-born granule cells (abGCs) in the CA2 region are essential for retrieving remote developmental memories of the mother in adult mice.
Introduction
Early social memories, particularly of the mother, are crucial for social recognition and preference in mice.
Results
Ablation of abGCs impairs the ability to discriminate between caregiving and novel mothers, which is restored after regeneration of new neurons.
Inhibition of abGC projections to the CA2 temporarily prevents the retrieval of remote mother memories.
Differentiating features of CA2 network activity are influenced by abGCs, enabling discrimination between social stimuli.
Discussion
The study highlights the importance of abGCs in supporting social memory retrieval and modulating CA2 network activity.
Materials and Methods
Detailed information on animal procedures, behavioral testing, surgical procedures, drug treatments, electrophysiology recordings, and histology.
Inquiry and Critical Thinking
How do abGCs influence social memory consolidation beyond the mother?
What counterarguments exist regarding the role of abGCs in social memory retrieval?
How might the findings of this study impact our understanding of memory formation in humans?
Stats
Ablation of abGCs impairs the ability to discriminate between caregiving and novel mothers.
Chemogenetic inhibition of abGC projections to the CA2 prevents the retrieval of remote mother memories.
Inhibition of 4-6-week-old abGCs alters SWR generation and theta-mid-gamma PAC in the CA2 region.
Inhibition of 10-12-week-old abGCs has no significant effect on CA2 network activity during exposure to social stimuli.
Quotes
"Ablation of abGCs abolishes the difference in investigation time between mother and novel mother."
"Inhibition of 4-6-week-old abGCs prevents characteristic SWR production patterns during exposure to novel mothers."
"abGCs support CA2 network oscillations present during both encoding and retrieval of social memories."