Concetti Chiave
Gut and oral bacterial species are linked to coronary atherosclerosis and systemic inflammation, potentially serving as biomarkers or treatment targets.
Sintesi
The study explores the association between gut bacterial species, oral flora, and coronary atherosclerosis in asymptomatic individuals. Key highlights include:
Common oral bacteria, such as Streptococcus species, are linked to coronary atherosclerosis and inflammatory biomarkers.
Gut and oral microbiota profiles are related, suggesting a potential pathway for oral pathogenic bacteria to enter circulation.
Positive associations were found between specific bacterial species and coronary artery calcium scores, coronary plaque, and inflammatory biomarkers.
Streptococci species, especially S anginosus, S oralis subsp oralis, and S parasanguinis, were strongly correlated with coronary atherosclerosis.
The study suggests that gut bacterial species may contribute to atherogenesis and could be used as potential biomarkers or treatment targets in the future.
Statistiche
Among the 64 species correlated with coronary artery calcium scores, 51 showed a positive association.
Twenty-five bacterial species correlated with coronary artery calcium scores were also associated with coronary plaque by CT angiography.
Of the 54 species positively associated with coronary artery calcium scores, 13 tracked with C-reactive protein levels.
Citazioni
"If the associations between gut bacterial species and markers of coronary atherosclerosis are found to be causal, such bacteria may contribute to atherogenesis by direct infection or by altering host metabolism." - Report