Women with early-stage endometrial cancer, particularly those at high risk for recurrence, are often treated with radiation after surgery. A study by researchers from Stanford University found that abnormal beta-catenin expression is associated with an increased risk of vaginal recurrence in endometrial cancer patients. Adjuvant radiation therapy can prevent vaginal recurrences in patients with abnormal beta-catenin expression. The study included 80 women with abnormal expression out of a total of 213 patients, showing no vaginal recurrences in those who received radiation compared to 10 recurrences in those who did not. The association between abnormal beta-catenin expression and vaginal recurrences remained significant even after controlling for other factors. Adjuvant radiation was particularly beneficial for patients with abnormal beta-catenin expression, improving local control without affecting overall survival. Larger prospective studies are needed to confirm these findings before implementing beta-catenin assessment in clinical practice.
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by M. Alexander... alle www.medscape.com 05-22-2023
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