Concetti Chiave
Our study reveals how neural networks orchestrate ionic waves in the brain, influencing cerebrospinal fluid perfusion and waste clearance, introducing a new theoretical framework for brain function.
Sintesi
The content discusses the role of neural networks in orchestrating large-amplitude, rhythmic ionic waves in the brain's interstitial fluid, impacting cerebrospinal fluid perfusion and waste clearance mechanisms. Chemogenetic manipulation impeding these waves hindered fluid infiltration and molecule clearance, while optogenetic stimulation enhanced fluid perfusion. Neurons are identified as crucial organizers for brain clearance processes, offering insights into macroscopic brain wave functions.
Statistiche
Chemogenetic flattening impeded cerebrospinal fluid infiltration and molecule clearance.
Optogenetic stimulation potentiated cerebrospinal fluid-to-interstitial fluid perfusion.