The study investigates the role of CNTN4 in the cortex, revealing reduced cortical thickness in Cntn4-/- mice. Neuronal morphology changes were observed in the motor cortex, indicating CNTN4's involvement in neuron structure. The interaction between CNTN4 and APP was identified, showing their relationship in controlling neural elongation. Knockout human cells confirmed the importance of this interaction for cell morphology and neurite outgrowth. These findings enhance our understanding of Alzheimer's disease, ASD, and neurodevelopment mechanisms.
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by Bamford,R. A... alle www.biorxiv.org 08-28-2023
https://www.biorxiv.org/content/10.1101/2023.08.25.554833v2Domande più approfondite