Telomeres play a crucial role in cancer progression, impacting immune signaling and tumor microenvironment. Telomere length influences TRF2 binding at the IL1R1 promoter, affecting NF-kappaB activation and cytokine expression. Telomere-sensitive IL1 signaling correlates with TAM infiltration in TNBC, highlighting the role of telomeres in modulating tumor immunity.
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by Mukherjee,A.... alle www.biorxiv.org 12-08-2021
https://www.biorxiv.org/content/10.1101/2021.12.07.471419v5Domande più approfondite