
腹側傍顔面領域(pFL)の異なる部位にビククリンを注入することで、能動呼吸の発生に関与する中心領域が特定された。特に、顔面神経核尾側端より前方0.6 mm及び0.8 mmの部位で最も強力かつ持続的な呼吸反応が観察された。


coremsg

The lateral parafacial area (pFL) is a crucial region involved in respiratory control, particularly in generating active expiration through an expiratory oscillatory network. Active expiration involves rhythmic abdominal (ABD) muscle contractions during late- expiration, increasing ventilation during elevated respiratory demands. The precise anatomical location of the expiratory oscillator within the ventral medulla’s rostro-caudal axis is debated. While some studies point to the caudal tip of the facial nucleus (VIIc) as the oscillator’s core, others suggest more rostral areas. Our study employed bicuculline (a GABA-A receptor antagonist) injections at various pFL sites (-0.2 to +0.8mm from VIIc) to investigate the impact of GABAergic disinhibition on respiration. These injections consistently elicited ABD recruitment, but the response strength varied along the rostro-caudal zone. Remarkably, the most robust and enduring changes in tidal volume, minute ventilation and combined respiratory responses occurred at more rostral pFL locations (+0.6/+0.8 mm from VIIc). Multivariate analysis of the respiratory cycle further differentiated between locations, revealing the core site for active expiration generation with this experimental approach. Our study advances our understanding of neural mechanisms governing active expiration and emphasizes the significance of investigating the rostral pFL region.

### Competing Interest Statement

The authors have declared no competing interest.

Mapping responses to focal injections of bicuculline in the lateral parafacial region identifies core regions for maximal generation of active expiration

呼吸制御における腹側傍顔面領域の機能的マッピング-最大の能動呼吸発生に関与する中心領域の特定


呼吸制御における腹側傍顔面領域の機能的マッピング - 最大の能動呼吸発生に関与する中心領域の特定
