
The Jag2/Notch1 signaling axis is essential for proper sebocyte differentiation in adult skin, and its inhibition retains sebaceous gland stem/progenitor cells in a proliferative state, blocking further differentiation.


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The sebaceous gland (SG) is a vital appendage of the epidermis, and its normal homeostasis and function is crucial for effective maintenance of the skin barrier. Notch signaling is a well-known regulator of epidermal differentiation, and has also been shown to be involved in postnatal maintenance of SGs. However, the precise role of Notch signaling in regulating SG differentiation in the adult homeostatic skin remains unclear. While there is evidence to suggest that Notch1 is the primary Notch receptor involved in regulating the differentiation process, the ligand remains unknown. Using monoclonal therapeutic antibodies designed to specifically inhibit of each of the Notch ligands or receptors, we have identified the Jag2/Notch1 signaling axis as the primary regulator of sebocyte differentiation in homeostatic skin. Mature sebocytes are lost upon specific inhibition of the Jag2 ligand or Notch1 receptor, resulting in the accumulation of proliferative stem/progenitor cells in the SG. Most strikingly, this phenotype is reversible, as these stem/progenitor cells re-enter differentiation when the inhibition of Notch activity is lifted. Thus, Notch activity promotes correct sebocyte differentiation, and is required to restrict progenitor proliferation.

### Competing Interest Statement

The authors have declared no competing interest.

The Jag2/Notch1 signaling axis promotes sebaceous gland differentiation and controls progenitor proliferation

the-jag2-notch1-signaling-axis-regulates-sebaceous-gland-differentiation-and-progenitor-proliferation-in-adult-skin


The Jag2/Notch1 Signaling Axis Regulates Sebaceous Gland Differentiation and Progenitor Proliferation in Adult Skin
