核心概念
Recently immunized febrile infants aged 6-12 weeks have a significantly lower risk of serious bacterial infections, especially within the first 24 hours after immunization, compared to non-recently immunized febrile infants.
要約
The study evaluated 508 febrile infants aged 6-12 weeks who presented at two US military academic emergency departments over 4 years. 114 of these infants were categorized as "recently immunized" (within 72 hours before emergency department visit) and the rest as "not recently immunized".
The key findings are:
- The prevalence of serious bacterial infections (SBIs) was 3.5% in recently immunized infants, compared to 13.7% in non-recently immunized infants.
- Among recently immunized infants, the prevalence of SBIs was lower in those immunized within the first 24 hours (2%) compared to those immunized more than 24 hours before (14.3%).
- Almost all identified SBI cases were urinary tract infections, with only one case of pneumonia in an infant with respiratory symptoms within 24 hours of immunization.
The study suggests that physicians should consider a less invasive approach, such as obtaining a urinalysis, when evaluating recently immunized febrile infants, especially those presenting within 24 hours of immunization. This is in line with the general recommendation to obtain a urinalysis for all recently immunized febrile infants over 60 days.
The study's limitations include small sample size, retrospective design, and potential biases from the military healthcare setting. Further research is needed to confirm the findings and their generalizability.
統計
The prevalence of serious bacterial infections (SBIs) was 3.5% in recently immunized febrile infants and 13.7% in non-recently immunized febrile infants.
Among recently immunized infants, the prevalence of SBIs was 2% in those immunized within the first 24 hours and 14.3% in those immunized more than 24 hours before.
引用
"The prevalence of SBI was 3.5% in the recently immunized febrile infants and 13.7% in not recently immunized febrile infants."
"Among the recently immunized infants, the prevalence of SBI was lower in those immunized within the first 24 hours than those immunized more than 24 hours before ED presentation (2% vs 14.3%, respectively)."