핵심 개념
Adhesive implant-tissue interfaces can effectively mitigate fibrous capsule formation around implanted biomaterials and devices across diverse organ models by reducing inflammatory cell infiltration.
초록
The content describes a study that demonstrates the effectiveness of adhesive implant-tissue interfaces in preventing fibrous capsule formation around implanted biomaterials and devices. The key findings are:
Adhesive implant-tissue interfaces were tested in various animal models, including rats, mice, humanized mice, and pigs, and were found to reduce the level of inflammatory cell infiltration compared to non-adhesive interfaces.
Histological analysis showed that the adhesive interfaces did not form observable fibrous capsules on diverse organs, including the abdominal wall, colon, stomach, lung, and heart, over a 12-week in vivo study.
In vitro experiments, including protein adsorption, multiplex Luminex assays, quantitative PCR, immunofluorescence analysis, and RNA sequencing, were conducted to validate the hypothesis.
The study also demonstrated that the adhesive interfaces enabled long-term bidirectional electrical communication in implantable electrodes in a rat model over 12 weeks.
The findings suggest that the adhesive implant-tissue interface approach may offer a promising strategy for long-term anti-fibrotic performance of implanted biomaterials and devices.
통계
The study was conducted over a 12-week period in vivo.
Diverse organ models were tested, including the abdominal wall, colon, stomach, lung, and heart.
인용구
"Implanted biomaterials and devices face compromised functionality and efficacy in the long term owing to foreign body reactions and subsequent formation of fibrous capsules at the implant–tissue interfaces."
"Histological analysis shows that the adhesive implant–tissue interface does not form observable fibrous capsules on diverse organs, including the abdominal wall, colon, stomach, lung and heart, over 12 weeks in vivo."