The study focuses on ASAR RNAs' role in controlling replication timing and chromosome stability. It identifies key RBPs interacting with ASAR RNAs and demonstrates the impact of their depletion on replication timing across all autosome pairs. The findings suggest a crucial function for ASARs as essential RNA scaffolds for maintaining chromosomal integrity.
The research highlights the significance of an ∼7kb domain within ASAR6-141 RNA, showing its critical role in controlling replication timing of entire chromosomes. Depletion of specific RBPs results in dissociation of ASAR RNAs from chromosome territories, disrupting synchronous replication on all autosome pairs. These results emphasize the intricate relationship between ASAR RNAs and RBPs in regulating genome-wide replication dynamics.
Furthermore, the study explores the potential mechanisms by which ASARs interact with RBPs to influence replication timing, proposing a model where ASAR RNAs serve as scaffolds for forming protein complexes that regulate chromatin structure and DNA replication machinery. The findings suggest a novel perspective on how non-coding RNAs contribute to genome-wide processes such as chromosome dynamics and replication timing.
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by Thayer,M. J.... 게시일 www.biorxiv.org 06-04-2022
https://www.biorxiv.org/content/10.1101/2022.06.04.494840v3더 깊은 질문