핵심 개념
Local therapies for advanced prostate cancer lead to more side effects than systemic treatments, impacting patients' quality of life.
초록
The article discusses a retrospective cohort study published in JAMA Network Open that focused on the side effects of local therapies for advanced prostate cancer compared to systemic treatments. Key points include:
- Local therapies like radiation therapy and radical prostatectomy result in more gastrointestinal, sexual, and incontinence issues.
- The study aimed to evaluate the impact of local therapy on quality of life compared to androgen deprivation therapy (ADT).
- Examining side effects up to 5 years post-treatment in 5500 US veterans diagnosed with advanced prostate cancer.
- Men undergoing local therapy reported higher prevalence of side effects lasting 2 to 5 years compared to systemic therapy recipients.
- Notable differences in gastrointestinal issues, pain, sexual dysfunction, and urinary problems between local and systemic therapy groups.
- Contradictory data compared to other studies, raising questions about the effectiveness and side effects of local therapies.
- Importance of informing patients about potential side effects of local therapy for marginal survival improvements.
- Variations in patient populations and treatment structures may influence study outcomes.
통계
"Men who underwent local therapy, compared with those who underwent systemic therapy, experienced more of the following symptoms: Gastrointestinal issues (odds ratio [OR], 4.08)"
"Men who underwent local therapy, compared with those who underwent systemic therapy, experienced more of the following symptoms: Pain (OR, 1.57)"
"Men who underwent local therapy, compared with those who underwent systemic therapy, experienced more of the following symptoms: Sexual dysfunction (OR, 2.96)"
"Men who underwent local therapy, compared with those who underwent systemic therapy, experienced more of the following symptoms: Urinary problems, predominantly incontinence (OR, 2.25)"
인용구
"As practitioners, we sometimes underestimate the side effects we subject our patients to. We need to talk to our patients about the prognosis improvement that comes with side effects." - Hubert Kübler